![]() ![]() Thiamine is indicated for the treatment of suspected or manifest WE. MRI should be used to support the diagnosis of acute WE both in alcoholics and non alcoholics (Level B). Total thiamine in blood sample should be measured immediately before its administration (GPP). The clinical diagnosis of WE in alcoholics requires two of the following four signs (i) dietary deficiencies (ii) eye signs, (iii) cerebellar dysfunction, and (iv) either an altered mental state or mild memory impairment (Level B). The clinical diagnosis of WE should take into account the different presentations of clinical signs between alcoholics and non alcoholics (Recommendation Level C) although prevalence is higher in alcoholics, WE should be suspected in all clinical conditions which could lead to thiamine deficiency (good practice point – GPP). Methods: We searched MEDLINE, EMBASE, LILACS, Cochrane Library. Objectives: To create practical guidelines for diagnosis, management and prevention of the disease. ![]() Background: Although Wernicke encephalopathy (WE) is a preventable and treatable disease it still often remains undiagnosed during life. ![]()
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